The pulmonary deposition and retention of indium-111 labeled ultrafine carbon particles in healthy individuals.
Identifieur interne : 000982 ( Main/Exploration ); précédent : 000981; suivant : 000983The pulmonary deposition and retention of indium-111 labeled ultrafine carbon particles in healthy individuals.
Auteurs : RBID : pubmed:22906170English descriptors
- KwdEn :
- Adult, Aerosols, Algorithms, Biological Transport, Carbon (chemistry), Female, Follow-Up Studies, Humans, Indium Radioisotopes, Inhalation Exposure, Lung (drug effects), Lung (metabolism), Lung (radionuclide imaging), Male, Middle Aged, Particle Size, Particulate Matter (analysis), Particulate Matter (blood), Particulate Matter (chemistry), Particulate Matter (pharmacokinetics), Physicochemical Phenomena, Radionuclide Imaging, Respiratory Mucosa (drug effects), Respiratory Mucosa (metabolism), Respiratory Mucosa (radionuclide imaging), Tissue Distribution, Young Adult.
- MESH :
- chemical , analysis : Particulate Matter.
- chemical , blood : Particulate Matter.
- chemical , chemistry : Carbon, Particulate Matter.
- chemical , pharmacokinetics : Particulate Matter.
- chemical : Aerosols, Indium Radioisotopes.
- drug effects : Lung, Respiratory Mucosa.
- metabolism : Lung, Respiratory Mucosa.
- radionuclide imaging : Lung, Respiratory Mucosa.
- Adult, Algorithms, Biological Transport, Female, Follow-Up Studies, Humans, Inhalation Exposure, Male, Middle Aged, Particle Size, Physicochemical Phenomena, Radionuclide Imaging, Tissue Distribution, Young Adult.
Abstract
Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body.
DOI: 10.3109/08958378.2012.708065
PubMed: 22906170
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The pulmonary deposition and retention of indium-111 labeled ultrafine carbon particles in healthy individuals.</title><author><name sortKey="Klepczy Ska Nystr M, Anna" uniqKey="Klepczy Ska Nystr M A">Anna Klepczyńska-Nyström</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health Sciences, Division of Occupational and Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health Sciences, Division of Occupational and Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez Crespo, Alejandro" uniqKey="Sanchez Crespo A">Alejandro Sanchez-Crespo</name></author><author><name sortKey="Andersson, Martin" uniqKey="Andersson M">Martin Andersson</name></author><author><name sortKey="Falk, Rolf" uniqKey="Falk R">Rolf Falk</name></author><author><name sortKey="Lundin, Anders" uniqKey="Lundin A">Anders Lundin</name></author><author><name sortKey="Larsson, Britt Marie" uniqKey="Larsson B">Britt-Marie Larsson</name></author><author><name sortKey="Svartengren, Magnus" uniqKey="Svartengren M">Magnus Svartengren</name></author></titleStmt><publicationStmt><date when="2012">2012</date><idno type="doi">10.3109/08958378.2012.708065</idno><idno type="RBID">pubmed:22906170</idno><idno type="pmid">22906170</idno><idno type="wicri:Area/Main/Corpus">000B13</idno><idno type="wicri:Area/Main/Curation">000B13</idno><idno type="wicri:Area/Main/Exploration">000982</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aerosols</term><term>Algorithms</term><term>Biological Transport</term><term>Carbon (chemistry)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Indium Radioisotopes</term><term>Inhalation Exposure</term><term>Lung (drug effects)</term><term>Lung (metabolism)</term><term>Lung (radionuclide imaging)</term><term>Male</term><term>Middle Aged</term><term>Particle Size</term><term>Particulate Matter (analysis)</term><term>Particulate Matter (blood)</term><term>Particulate Matter (chemistry)</term><term>Particulate Matter (pharmacokinetics)</term><term>Physicochemical Phenomena</term><term>Radionuclide Imaging</term><term>Respiratory Mucosa (drug effects)</term><term>Respiratory Mucosa (metabolism)</term><term>Respiratory Mucosa (radionuclide imaging)</term><term>Tissue Distribution</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Particulate Matter</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Particulate Matter</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Carbon</term><term>Particulate Matter</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Particulate Matter</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Aerosols</term><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lung</term><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung</term><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Lung</term><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Algorithms</term><term>Biological Transport</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Inhalation Exposure</term><term>Male</term><term>Middle Aged</term><term>Particle Size</term><term>Physicochemical Phenomena</term><term>Radionuclide Imaging</term><term>Tissue Distribution</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22906170</PMID><DateCreated><Year>2012</Year><Month>08</Month><Day>21</Day></DateCreated><DateCompleted><Year>2013</Year><Month>01</Month><Day>16</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1091-7691</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>10</Issue><PubDate><Year>2012</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Inhalation toxicology</Title><ISOAbbreviation>Inhal Toxicol</ISOAbbreviation></Journal><ArticleTitle>The pulmonary deposition and retention of indium-111 labeled ultrafine carbon particles in healthy individuals.</ArticleTitle><Pagination><MedlinePgn>645-51</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3109/08958378.2012.708065</ELocationID><Abstract><AbstractText Label="CONTEXT" NlmCategory="BACKGROUND">Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbon particles in healthy subjects. Additionally, the possibility to extend the follow-up period to 4 weeks was also investigated for one of the subjects.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The cumulative pulmonary particle clearance 1 week post-administration, corrected for activity leaching and mucocilliary transport of activity deposited in the central airways, was 4.3 ± 8.5% (average ± standard deviation at group level), with marginal translocation of particles from lungs to blood, 0.3%. There was no observable elimination of particles from the body via urine. Seven days after exposure, the cumulated activity leaching was 3% (group level), which indicates a stable bonding between the particles and Indium-111. The volunteer followed for a total of 4 weeks, showed a cumulative decrease of activity retention in the lungs of 10.5%. After correction for activity leaching and clearance from central airway deposition, the estimated particle clearance was about 2%.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">No evidence for particle translocation from the lungs could be proven 7 days after exposure. It is possible to follow-up Indium-111 labeled UF carbon particles at least 1 month post-administration without increasing the administered activity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Klepczyńska-Nyström</LastName><ForeName>Anna</ForeName><Initials>A</Initials><Affiliation>Department of Public Health Sciences, Division of Occupational and Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.</Affiliation></Author><Author ValidYN="Y"><LastName>Sanchez-Crespo</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Andersson</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Falk</LastName><ForeName>Rolf</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Lundin</LastName><ForeName>Anders</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Larsson</LastName><ForeName>Britt-Marie</ForeName><Initials>BM</Initials></Author><Author ValidYN="Y"><LastName>Svartengren</LastName><ForeName>Magnus</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Inhal Toxicol</MedlineTA><NlmUniqueID>8910739</NlmUniqueID><ISSNLinking>0895-8378</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Aerosols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Particulate Matter</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-44-0</RegistryNumber><NameOfSubstance>Carbon</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aerosols</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Biological Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Carbon</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Inhalation Exposure</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lung</DescriptorName><QualifierName MajorTopicYN="N">drug effects</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Particle Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Particulate Matter</DescriptorName><QualifierName MajorTopicYN="N">analysis</QualifierName><QualifierName MajorTopicYN="N">blood</QualifierName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Physicochemical Phenomena</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radionuclide Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Respiratory Mucosa</DescriptorName><QualifierName MajorTopicYN="N">drug effects</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.3109/08958378.2012.708065</ArticleId><ArticleId IdType="pubmed">22906170</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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